William Whetstone, MD

Publications: 

254 Initiation of Low Molecular Weight Heparin Within 24 Hours Is Safe and Effective for VTE Prophylaxis in Spinal Cord Injury Patients.

Neurosurgery

Austin Lui, Timothy Chryssikos, Arati Patel, Christine Park, Abel Torres, Nikolaos Kyritsis, Debra P. Hemmerle, Xuan Duong Fernandez, Rajiv Saigal, Jason Talbott, Jonathan S. Pan, Adam Ferguson, William Whetstone, Vineeta Singh, Philip R. Weinstein, Sanjay S. Dhall, Praveen V. Mummaneni, J. Russell Huie, Lisa U. Pascual, Geoffrey Manley, Jacqueline Bresnahan, Michael Beattie, Anthony Michael DiGiorgio

ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke.

Clinical and translational medicine

Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du Q, Xiao Z, Chang Y, Lv P, Huie JR, Torres-Espin A, Ferguson AR, Hemmerle DD, Talbott JF, Weinstein PR, Pascual LU, Singh V, DiGiorgio AM, Saigal R, Whetstone WD, Manley GT, Dhall SS, Bresnahan JC, Maze M, Jiang X, Singhal NS, Beattie MS, Su H, Guan Z

Correction: Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome.

PloS one

Chou A, Torres-Espin A, Kyritsis N, Huie JR, Khatry S, Funk J, Hay J, Lofgreen A, Shah R, McCann C, Pascual LU, Amorim E, Weinstein PR, Manley GT, Dhall SS, Pan JZ, Bresnahan JC, Beattie MS, Whetstone WD, Ferguson AR, TRACK-SCI Investigators

Safety and comparative efficacy of initiating low-molecular-weight heparin within 24 hours of injury or surgery for venous thromboembolism prophylaxis in patients with spinal cord injury: a prospective TRACK-SCI registry study.

Neurosurgical focus

Lui A, Park C, Chryssikos T, Radabaugh H, Patel A, Aabedi AA, Ferguson AR, Torres Espin A, Mummaneni PV, Dhall SS, Duong-Fernandez X, Saigal R, Chou A, Pan J, Singh V, Hemmerle DD, Kyritsis N, Talbott JF, Pascual LU, Huie JR, Whetstone WD, Bresnahan JC, Beattie MS, Weinstein PR, Manley GT, DiGiorgio AM

188 American Spinal Injury Association (ASIA) Impairment Scale (AIS) Conversion Underestimates Neurological Recovery Following Traumatic Spinal Cord Injury.

Neurosurgery

Winward Choy, Nikolaos Kyritsis, Xuan Duong Fernandez, Adam Ferguson, Debra P. Hemmerle, Lisa U. Pascual, Vineeta Singh, Jason Talbott, Jonathan Pan, Abel Torres, William Whetstone, J. Russell Huie, Kenneth Fond, Anastasia Keller, Jacqueline Bresnahan, Michael Beattie, Anthony Michael DiGiorgio, Sanjay S. Dhall, Rajiv Saigal

Hypotension requiring vasopressor treatment and increased cardiac complications in elderly spinal cord injury patients: a prospective TRACK-SCI registry study.

Journal of neurosurgery. Spine

Agarwal N, Blitstein J, Lui A, Torres-Espin A, Vasnarungruengkul C, Burke J, Mummaneni PV, Dhall SS, Weinstein PR, Duong-Fernandez X, Chou A, Pan J, Singh V, Ferguson AR, Hemmerle DD, Kyritsis N, Talbott JF, Whetstone WD, Bresnahan JC, Beattie MS, Manley GT, DiGiorgio A

Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome.

PloS one

Chou A, Torres-Espin A, Kyritsis N, Huie JR, Khatry S, Funk J, Hay J, Lofgreen A, Shah R, McCann C, Pascual LU, Amorim E, Weinstein PR, Manley GT, Dhall SS, Pan JZ, Bresnahan JC, Beattie MS, Whetstone WD, Ferguson AR, TRACK-SCI Investigators

Decision tree-based machine learning analysis of intraoperative vasopressor use to optimize neurological improvement in acute spinal cord injury.

Neurosurgical focus

Agarwal N, Aabedi AA, Torres-Espin A, Chou A, Wozny TA, Mummaneni PV, Burke JF, Ferguson AR, Kyritsis N, Dhall SS, Weinstein PR, Duong-Fernandez X, Pan J, Singh V, Hemmerle DD, Talbott JF, Whetstone WD, Bresnahan JC, Manley GT, Beattie MS, DiGiorgio AM

Appendicular Fracture and Polytrauma Correlate with Outcome of Spinal Cord Injury: A Transforming Research and Clinical Knowledge in Spinal Cord Injury Study.

Journal of neurotrauma

Miclau TA, Torres-Espin A, Morshed S, Morioka K, Huie JR, El Naga AN, Chou A, Pascual L, Duong-Fernandez X, Kuo YH, Weinstein P, Dhall SS, Bresnahan JC, Beattie MS, Digiorgio A, Ferguson AR, Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI) Investigators

Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury.

eLife

Torres-Espín A, Haefeli J, Ehsanian R, Torres D, Almeida CA, Huie JR, Chou A, Morozov D, Sanderson N, Dirlikov B, Suen CG, Nielson JL, Kyritsis N, Hemmerle DD, Talbott JF, Manley GT, Dhall SS, Whetstone WD, Bresnahan JC, Beattie MS, McKenna SL, Pan JZ, Ferguson AR, TRACK-SCI Investigators

Diagnostic blood RNA profiles for human acute spinal cord injury.

The Journal of experimental medicine

Kyritsis N, Torres-Espín A, Schupp PG, Huie JR, Chou A, Duong-Fernandez X, Thomas LH, Tsolinas RE, Hemmerle DD, Pascual LU, Singh V, Pan JZ, Talbott JF, Whetstone WD, Burke JF, DiGiorgio AM, Weinstein PR, Manley GT, Dhall SS, Ferguson AR, Oldham MC, Bresnahan JC, Beattie MS

Meeting Proceedings for SCI 2020: Launching a Decade of Disruption in Spinal Cord Injury Research.

Journal of neurotrauma

Morse LR, Field-Fote EC, Contreras-Vidal J, Noble-Haeusslein LJ, Rodreick M, Shields RK, Sofroniew M, Wudlick R, Zanca JM, SCI 2020 Working Group

Atlas-based Volumetric Analysis of Blunt Spinal Cord Contusion Injury.

Neurosurgery

John F Burke, Nikhil Mummaneni, Adam Ferguson, J. Russell Huie, Leigh H Thomas, Lisa Pascual, Anthony M DiGiorgio, Debra P Hemmerle, Vineeta Singh, Abel Torres, Nikolaos Kyritsis, Philip R Weinstein, William Whetstone, Sanjay S Dhall, Xuan Duong Fernandez, Michael Beattie, Jacqueline Bresnahan, Jason Talbott

Injury volume extracted from MRI predicts neurologic outcome in acute spinal cord injury: A prospective TRACK-SCI pilot study.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Mummaneni N, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris M, Pascual LU, Ferguson AR, Russell Huie J, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Weinstein PR, Whetstone WD, Manley GT, Bresnahan JC, Beattie MS, Cohen-Adad J, Dhall SS, Talbott JF

XGBoost, a Machine Learning Method, Predicts Neurological Recovery in Patients with Cervical Spinal Cord Injury.

Neurotrauma reports

Inoue T, Ichikawa D, Ueno T, Cheong M, Inoue T, Whetstone WD, Endo T, Nizuma K, Tominaga T

Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics.

Neurosurgical focus

Tsolinas RE, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris MH, Yue JK, Winkler EA, Suen CG, Pascual LU, Ferguson AR, Huie JR, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Haefeli J, Weinstein PR, de Almeida Neto CA, Kuo YH, Taggard D, Talbott JF, Whetstone WD, Manley GT, Bresnahan JC, Beattie MS, Dhall SS

Clinical implementation of a novel spinal cord perfusion pressure protocol in acute traumatic spinal cord injury at a U.S. Level I trauma center: A TRACK-SCI study.

World neurosurgery

Yue JK, Hemmerle DP, Winkler EA, Thomas LH, Fernandez XD, Kyritsis N, Pan JZ, Pascual LU, Singh V, Weinstein PR, Talbott JF, Huie JR, Ferguson AR, Whetstone WD, Manley GT, Beattie MS, Bresnahan JC, Mummaneni PV, Dhall SS

Initial Experience of Spinal Cord Perfusion Pressure Goals in Lieu of Mean Arterial Pressure Goals in Acute Traumatic Spinal Cord Injury at a United States Level I Trauma Center: A Transforming Research and Clinical Knowledge-Spinal Cord Injury Study.

Neurosurgery

John K Yue, Debra P Hemmerle, Hansen Deng, Ethan A Winkler, Leigh H Thomas, Xuan Duong Fernandez, Pavan S Upadhyayula, Nikolaos Kyritsis, Lisa U Pascual, Vineeta Singh, Philip R Weinstein, Jason Talbott, J Russell Huie, Adam Ferguson, William Whetstone, Geoffrey T Manley, Michael Beattie, Jacqueline Bresnahan, Praveen V Mummaneni, Sanjay S Dhall

In Reply: Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury.

Neurosurgery

Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan JZ, Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS

Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury.

Neurosurgery

Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan JZ, Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS

Convolutional Neural Network-Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury.

AJNR. American journal of neuroradiology

McCoy DB, Dupont SM, Gros C, Cohen-Adad J, Huie RJ, Ferguson A, Duong-Fernandez X, Thomas LH, Singh V, Narvid J, Pascual L, Kyritsis N, Beattie MS, Bresnahan JC, Dhall S, Whetstone W, Talbott JF

Value of aggressive surgical and intensive care unit in elderly patients with traumatic spinal cord injury.

Neurosurgical focus

Lau D, Dalle Ore CL, Tarapore PE, Huang M, Manley G, Singh V, Mummaneni PV, Beattie M, Bresnahan J, Ferguson AR, Talbott JF, Whetstone W, Dhall SS

Yield of Emergent CT in Patients With Epilepsy Presenting With a Seizure.

The Neurohospitalist

Kvam KA, Douglas VC, Whetstone WD, Josephson SA, Betjemann JP

Motor Evoked Potentials Correlate With Magnetic Resonance Imaging and Early Recovery After Acute Spinal Cord Injury.

Neurosurgery

Dhall SS, Haefeli J, Talbott JF, Ferguson AR, Readdy WJ, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Whetstone WD

Low Yield of Paired Head and Cervical Spine Computed Tomography in Blunt Trauma Evaluation.

The Journal of emergency medicine

Graterol J, Beylin M, Whetstone WD, Matzoll A, Burke R, Talbott J, Rodriguez RM

Data-Driven Comparison Of Acute Imaging Biomarkers For Spinal Cord Injury: A Prospective TRACK-SCI Pilot Study (S42.006).

Neurology

J. Russell Huie, Jason Talbott, Vineeta Singh, Xuan Duong Fernandez, Rachel Tsolinas, Lisa Pascual, Jonathan Pan, Nikolaos Kyritsis, Dolores Torres, Michael Beattie, Jacqueline Bresnahan, Adam Ferguson, Sanjay Dhall, William Whetstone

Safety and effectiveness of early chemical deep venous thrombosis prophylaxis after spinal cord injury: pilot prospective data.

Neurosurgical focus

DiGiorgio AM, Tsolinas R, Alazzeh M, Haefeli J, Talbott JF, Ferguson AR, Bresnahan JC, Beattie MS, Manley GT, Whetstone WD, Mummaneni PV, Dhall SS

Multivariate Analysis of MRI Biomarkers for Predicting Neurologic Impairment in Cervical Spinal Cord Injury.

AJNR. American journal of neuroradiology

Haefeli J, Mabray MC, Whetstone WD, Dhall SS, Pan JZ, Upadhyayula P, Manley GT, Bresnahan JC, Beattie MS, Ferguson AR, Talbott JF

Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury.

Neurosurgery

Readdy WJ, Saigal R, Whetstone WD, Mefford AN, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley GT, Dhall SS

Higher Mean Arterial Pressure Values Correlate with Neurologic Improvement in Patients with Initially Complete Spinal Cord Injuries.

World neurosurgery

Catapano JS, John Hawryluk GW, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G

182 Ultra-Early (<12 Hours) Decompression Improves Recovery After Spinal Cord Injury Compared to Early (12-24 Hours) Decompression.

Neurosurgery

Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott J, Pan J, Ferguson A, Beattie M, Bresnahan J, Haefeli J, Whetstone W, Suen C, Huang MC, Manley GT, Tarapore PE, Dhall SS

Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury.

Neurosurgery

Readdy WJ, Saigal R, Whetstone WD, Mefford A, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley GT, Dhall SS

Multidimensional Analysis of Magnetic Resonance Imaging Predicts Early Impairment in Thoracic and Thoracolumbar Spinal Cord Injury.

Journal of neurotrauma

Mabray MC, Talbott JF, Whetstone WD, Dhall SS, Phillips DB, Pan JZ, Manley GT, Bresnahan JC, Beattie MS, Haefeli J, Ferguson AR

Mean Arterial Blood Pressure Correlates with Neurological Recovery after Human Spinal Cord Injury: Analysis of High Frequency Physiologic Data.

Journal of neurotrauma

Hawryluk G, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G

Complications and outcomes of vasopressor usage in acute traumatic central cord syndrome.

Journal of neurosurgery. Spine

Readdy WJ, Whetstone WD, Ferguson AR, Talbott JF, Inoue T, Saigal R, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Dhall SS

The Brain and Spinal Injury Center score: a novel, simple, and reproducible method for assessing the severity of acute cervical spinal cord injury with axial T2-weighted MRI findings.

Journal of neurosurgery. Spine

Talbott JF, Whetstone WD, Readdy WJ, Ferguson AR, Bresnahan JC, Saigal R, Hawryluk GW, Beattie MS, Mabray MC, Pan JZ, Manley GT, Dhall SS

A Simple, Real-Time Text-Messaging Intervention Is Associated with Improvements Door-to-Needle Times for Acute Ischemic Stroke (S02.007).

Neurology

Molly Burnett, Lara Zimmermann, Zlatan Coralic, Tina Quon, William Whetstone, Anthony Kim

The use of neuroimaging studies and neurological consultation to evaluate dizzy patients in the emergency department.

The Neurohospitalist

Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS

Rate and predictors of serious neurologic causes of dizziness in the emergency department.

Mayo Clinic proceedings

Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS

Application of the ABCD2 score to identify cerebrovascular causes of dizziness in the emergency department.

Stroke

Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS

Age is a determinant of leukocyte infiltration and loss of cortical volume after traumatic brain injury.

Developmental neuroscience

Claus CP, Tsuru-Aoyagi K, Adwanikar H, Walker B, Manvelyan H, Whetstone W, Noble-Haeusslein LJ

Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets.

NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics

Potts MB, Koh SE, Whetstone WD, Walker BA, Yoneyama T, Claus CP, Manvelyan HM, Noble-Haeusslein LJ

Prehospital Management of SCI Individuals with Extremity Fractures

Topics in Spinal Cord Injury Rehabilitation

William Whetstone

Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing.

Journal of neuroscience research

Whetstone WD, Hsu JY, Eisenberg M, Werb Z, Noble-Haeusslein LJ